منابع مشابه
Meropenem pharmacokinetics in the newborn.
We studied meropenem in 23 pre-term (gestational age, 29 to 36 weeks) and 15 full-term (gestational age, 37 to 42 weeks) neonates. Meropenem doses of 10, 20, and 40 mg/kg were administered as single doses (30-min intravenous infusion) on a random basis. Blood was obtained for determining the meropenem concentration nine times. Each child required other antimicrobials for proven/suspected bacter...
متن کاملClinical Pharmacology of Meropenem in Neonates: Effects and Pharmacokinetics
Meropenem, a carbapenem antibiotic, has a broad-spectrum activity and is active against Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influencae, Moraxella catarrhalis, gram-negative enteric bacilli as Escherichia coli, Klebsiella, Enterobacter, Serratia and Pseudomonas aeruginosa. Meropenem has excellent penetration in body tissues and in cerebrospinal fluid (in the presenc...
متن کاملPharmacokinetics in the newborn.
In addition to differences in the pharmacodynamic response in the infant, the dose and the pharmacokinetic processes acting upon that dose principally determine the efficacy and/or safety of a therapeutic or inadvertent exposure. At a given dose, significant differences in therapeutic efficacy and toxicant susceptibility exist between the newborn and adult. Immature pharmacokinetic processes in...
متن کاملclinical pharmacology of meropenem in neonates: effects and pharmacokinetics
meropenem, a carbapenem antibiotic, has a broad-spectrum activity and is active against staphylococcus aureus, streptococcus pneumoniae, haemophilus influencae, moraxella catarrhalis, gram-negative enteric bacilli as escherichia coli, klebsiella, enterobacter, serratia and pseudomonas aeruginosa. meropenem has excellent penetration in body tissues and in cerebrospinal fluid (in the presence of ...
متن کاملPopulation pharmacokinetics of meropenem in febrile neutropenic patients in Korea.
Population pharmacokinetic parameters of meropenem in 57 febrile neutropenic patients and minimal inhibitory concentration (MIC) data for clinically isolated Pseudomonas aeruginosa and Escherichia coli were applied to estimate the time above the MIC (T>MIC) using the Monte Carlo simulation method. Mean population clearance (CL) and volume of distribution (V(d)) of meropenem were proportional to...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2009
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00351-09